Immunoglobulins are glycoproteins produced in the response to an immunogen by plasma cells and function as antibodies. General functions of immunoglobulins are antigen binding and effector functions. Immunoglobulins bind specifically to antigenic determinants and prevent the host from infections. Binding an antibody to antigen has no biological effect but binding antibodies triggers secondary effector function. Secondary effector function results in lysis of cells and helps in the release of biologically active material. Immunoglobulins have receptors for binding with lymphocytes, basophils, phagocytic cells, and platelets.
By this way, immunoglobulins trigger immunity of the host and help in spreading of infection to other parts of the body. Immunoglobulins are divided into five types based on differences in structure and they are IgG, IgM, IgA, IgD, and IgE. IgG is also called as circulating immunoglobulins and it can pass the placenta and helps in the development of passive immunity of fetus. IgM antibodies are produced in presence of bacteria and it is produced faster than other immunoglobulins. IgA is mostly found in GI tract, genito-urinary tract, and lungs and it acts as anti-inflammatory agents and prevents infection these parts. IgD immunoglobulins are used in the development of B cells (B cells produces antibodies). IgE immunoglobulins mainly involved in allergic reactions of the body.
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Increasing prevalence of immunodeficiency due to changing lifestyles drives the growth immunoglobulins market. Immunoglobulins are used in the treatment of immune deficiency. Increasing demand for immunoglobulins due to fewer side effects and increased bioavailability due to the biological origin. They are useful in the suppression of idiotypic antibodies, suppression of various inflammatory mediators (including chemokine’s, cytokines and metalloproteinase) and saturation of Fc receptors on macrophages. Changing regulatory scenario drives the growth. US FDA approved the use of immunoglobulins in case of chronic lymphocytic leukemia, Kawasaki disease, allogeneic bone marrow transplantation, common variable immunodeficiency, chronic inflammatory polyneuropathy, immune-mediated thrombocytopenia, primary immunodeficiency disorders and others. All these factors act as a driver in burgeoning growth of the immunoglobulins market.
Global Immunoglobulins market witnessed rapid growth due to rising demand for potential health benefits like immune modulation. Manufacturers are more focused on innovations to increase the applicability of immunoglobulins in other indications. Biotechnology companies work closely with research organizations and academic institutes for development of immunoglobulins by alternative means. In Developed countries, demand for immunoglobulins is increasing due to high awareness and others part of the market, manufacturers are mainly focused on marketing to increase awareness among the end user. Immunoglobulins market have a presence of many regional players which have a huge market share in emerging countries operating at regional or country level. The future of Immunoglobulins market is anticipated to grow at double CAGR during the forecast period.
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Global Immunoglobulins Market segmented into North America, Europe, Asia -Pacific & Japan, The Middle East and Africa regions and Latin America by region wise. North America dominates the global Immunoglobulins Market due to the high acceptance among patient populations, and in North America, USA is a major stakeholder due to the high awareness. Europe and Asia-pacific are the fastest growing market in Immunoglobulins Market due to raising awareness. The economic conditions in Asia-pacific region rise the Immunoglobulins market to new heights. Latin America is growing at stable pace due to increasing penetration of immunoglobulins. The Middle East and Africa regions are showing significantly less growth because of less awareness regarding immunoglobulins during the forecasted period.
The key participants in Immunoglobulins Market are Amgen Inc, AbbVie Inc., Gilead Sciences, Novartis AG, Johnson & Johnson, Merck & Co., Inc. F. Hoffmann-La Roche Ltd and others. The companies are mainly focusing on intense marketing to convey health benefits of Immunoglobulins.
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